Applications of Mass spectrometry

Applications of Mass spectrometry

Mass spectrometry is applicable across diverse fields, including forensic toxicology, metabolomics, proteomics, pharma/biopharma, and clinical research. Specific applications of mass spectrometry include drug testing and discovery, food contamination detection, pesticide residue analysis, isotope ratio determination, protein identification, and carbon dating.

Listed below are some application areas in which mass spectrometry has been used to discover, deduce, and quantify sample compounds.

Applications of mass spectrometry in proteomics - Characterization of proteins and protein complexes, sequencing of peptides, and identification of posttranslational modifications.

Applications of mass spectrometry in metabolomics - Cancer screening and diagnosis, global metabolic fingerprinting analysis, biomarker discovery and profiling, biofuels generation and use, lipidomics studies, and metabolic disorder profiling.

Applications of mass spectrometry in environmental analysis - Drinking water testing, pesticide screening and quantitation, soil contamination assessment, carbon dioxide and pollution monitoring, and trace elemental analysis of heavy metals leaching.

Applications of mass spectrometry in pharmaceutical analysis - Drug discovery and absorption, distribution, metabolism, and elimination (ADME) studies, pharmacokinetic and pharmacodynamic analyses, metabolite screening, and preclinical development.

Applications of mass spectrometry in forensic analysis - Analysis of trace evidence (e.g., fibers in carpet, polymers in paint), arson investigation (e.g., fire accelerant), confirmation of drug abuse, and identification of explosive residues (bombing investigation).

Clinical applications of mass spectrometry - Clinical drug development, Phase 0 studies, clinical tests, disease screening, drug therapy monitoring, analysis of peptides used for diagnostic testing, and identification of infectious agents for targeted therapies.